Human metapneumovirus infection of organoid-derived human bronchial epithelium represents cell tropism and cytopathology as observed in in vivo models
Pau Ribó-Molina; Stefan van Nieuwkoop; Anna Z. Mykytyn; Peter van Run; Mart M. Lamers; Bart L. Haagmans; Ron A. M. Fouchier; Bernadette van den Hoogen · 2024 · mSphere
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Human metapneumovirus (HMPV), a member of the Pneumoviridae family, causes upper and lower respiratory tract infections in humans. In vitro studies with HMPV have mostly been performed in monolayers of undifferentiated epithelial cells. In vivo studies in cynomolgus macaques and cotton rats have shown that ciliated epithelial cells are the main target of HMPV infection, but these observations cannot be studied in monolayer systems. Here, we established an organoid-derived bronchial culture model that allows physiologically relevant studies on HMPV. Inoculation with multiple prototype
Abstract by Pau Ribó-Molina; Stefan van Nieuwkoop; Anna Z. Mykytyn; Peter van Run; Mart M. Lamers; Bart L. Haagmans; Ron A. M. Fouchier; Bernadette van den Hoogen, mSphere (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1128/msphere.00743-23