A Single-Arm Phase 2 Trial of Doxorubicin Plus Zalifrelimab (Anti-CTLA-4 Antibody) and Balstilimab (Anti-PD-1 Antibody) in Advanced/Metastatic Soft Tissue Sarcomas.
Wilky BA; Julian KA; Maleddu A; Mailhot AC; Cartwright CR; Gao D; Moreno Tellez C; Kemp LE · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Purpose Doxorubicin is standard chemotherapy for metastatic soft tissue sarcomas (STS) but also enhances innate/adaptive immune responses by inducing immunogenic cell death. Most STS are immune "cold" tumors that do not respond to immune…
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Metadata source: Europe PMC · DOI 10.1158/1078-0432.ccr-25-0618