Circulating PD-L1 levels change during bevacizumab-based treatment in recurrent glioma
Maximilian J. Mair; Aysegül Ilhan‐Mutlu; Sahra Pajenda; Barbara Kiesel; Adelheid Wöhrer; Georg Widhalm; Karin Dieckmann; Christine Marosi · 2021 · Cancer Immunology Immunotherapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
PURPOSE: In primary brain tumors, the efficacy of immune-modulating therapies is still under investigation as inflammatory responses are restricted by tight immunoregulatory mechanisms in the central nervous system. Here, we measured soluble PD-L1 (sPD-L1) in the plasma of patients with recurrent glioblastoma (GBM) and recurrent WHO grade II-III glioma treated with bevacizumab-based salvage therapy. METHODS: Thirty patients with recurrent GBM and 10 patients with recurrent WHO grade II-III glioma were treated with bevacizumab-based salvage therapy at the Medical University of Vienna. Prior to
Abstract by Maximilian J. Mair; Aysegül Ilhan‐Mutlu; Sahra Pajenda; Barbara Kiesel; Adelheid Wöhrer; Georg Widhalm; Karin Dieckmann; Christine Marosi, Cancer Immunology Immunotherapy (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1007/s00262-021-02951-2