Neoadjuvant Single-Cycle Pembrolizumab for Stage I-III MMR-Deficient Colon Cancer: The RESET-C Trial
Ismail Gögenür; Tobias Freyberg Justesen; Line Schmidt Tarpgaard; Mustafa Bulut; Torben F. Hansen; Lars Henrik Jensen; Hans Bjarke Rahr; Mikail Gögenur · 2026 · Journal of Clinical Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
PURPOSE: Neoadjuvant immune checkpoint inhibition has shown promise in localized deficient mismatch repair (dMMR) colorectal cancer, yet the optimal treatment duration, regimen, and methods for response evaluation remain undefined. This trial aimed to investigate the efficacy and safety of neoadjuvant pembrolizumab for patients with localized dMMR colon cancer. METHODS: Participants received a single cycle of pembrolizumab (4 mg/kg, max 400 mg, every-6-weeks dosing regimen), followed by a preoperative endoscopy with biopsies and surgery 3-5 weeks later. The primary end point was pathologic com
Abstract by Ismail Gögenür; Tobias Freyberg Justesen; Line Schmidt Tarpgaard; Mustafa Bulut; Torben F. Hansen; Lars Henrik Jensen; Hans Bjarke Rahr; Mikail Gögenur, Journal of Clinical Oncology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1200/jco-25-02274