Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients
Christopher C. Butler; Andrew Pinto; Victoria Harris; Jane Holmes; Najib M. Rahman; Lucy Cureton; Gail Hayward; Duncan B. Richards · 2026 · New England Journal of Medicine
WASTE classifies this as Replication Failure · AI classification, approximate
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Abstract
BACKGROUND: Nirmatrelvir-ritonavir has been shown to reduce progression to severe illness from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in unvaccinated high-risk outpatients. The effectiveness of nirmatrelvir-ritonavir in persons who have been vaccinated, infected naturally, or both is unclear. METHODS: In two open-label platform trials (PANORAMIC in the United Kingdom and CanTreatCOVID in Canada), we enrolled higher-risk adults (≥50 years of age or ≥18 years of age with coexisting conditions) in the community who tested positive for SARS-CoV-2 and had been unwell for 5 day
Abstract by Christopher C. Butler; Andrew Pinto; Victoria Harris; Jane Holmes; Najib M. Rahman; Lucy Cureton; Gail Hayward; Duncan B. Richards, New England Journal of Medicine (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1056/nejmoa2502457