Overlooked Candida glabrata petites are echinocandin tolerant, induce host inflammatory responses, and display poor in vivo fitness
Amir Arastehfar; Farnaz Daneshnia; Hrant Hovhannisyan; Diego Fuentes; Nathaly Cabrera; Christopher Quinteros; Macit İlkit; Nevzat Ünal · 2023 · mBio
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Small colony variants are relatively common among some bacterial species and are associated with poor prognosis and recalcitrant infections. Similarly, Candida glabrata— a major intracellular fungal pathogen—produces small and slow-growing respiratory-deficient colonies, termed “petite.” Despite reports of clinical petite C. glabrata strains, our understanding of petite behavior in the host remains obscure. Moreover, controversies exist regarding in-host petite fitness and its clinical relevance. Herein, we employed whole-genome sequencing (WGS), dual-RNAseq, and extensive ex vivo and
Abstract by Amir Arastehfar; Farnaz Daneshnia; Hrant Hovhannisyan; Diego Fuentes; Nathaly Cabrera; Christopher Quinteros; Macit İlkit; Nevzat Ünal, mBio (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1128/mbio.01180-23