Diacerein for Knee Osteoarthritis: A Randomized Clinical Trial.
Aitken D; Cai G; Hill CL; Cicuttini FM; Wluka AE; Wang Y; Keen HI; Thompson MJW · 2026 · JAMA internal medicine
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
Importance Knee osteoarthritis (OA) is disabling, with few effective treatments. Anti-inflammatory treatments may be effective for patients with an inflammatory phenotype. Objectives To evaluate the efficacy of the interleukin-1β blocker…
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Metadata source: Europe PMC · DOI 10.1001/jamainternmed.2025.8237