MR-guided Focused Ultrasound Facilitates Sonodynamic Therapy with 5-Aminolevulinic Acid in a Rat Glioma Model
Sheng‐Kai Wu; Marc A. Santos; Stuart L. Marcus; Kullervo Hynynen · 2019 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Glioblastoma multiforme (GBM) continues to have a dismal prognosis and significant efforts are being made to develop more effective treatment methods. Sonodynamic therapy (SDT) is an emerging modality for cancer treatment which combines ultrasound with sonosensitizers to produce a localized cytotoxic effect. It has long been known that ultrasound exposure can cause both thermal and non-thermal bioeffects and it remains an open question to what degree does temperature impact the efficacy of SDT. In order to optimize the ultrasound parameters of SDT, transcranial MRI-guided focused ultr
Abstract by Sheng‐Kai Wu; Marc A. Santos; Stuart L. Marcus; Kullervo Hynynen, Scientific Reports (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-019-46832-2