Temporary deterioration of health and behavior during pexidartinib-mediated microglia depletion and repopulation in progranulin-deficient mice
Weyer M; Hahnefeld L; Franck L; Schreiber Y; Angioni C; Schäfer MK; Tegeder I · 2026 · Preprint
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Progranulin (PGRN) is a neurotrophic and anti-inflammatory factor produced mainly by neurons and microglia in the central nervous system. Progranulin haploinsufficiency causes frontotemporal dementia (FTD). In a previous study we showed…
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Metadata source: Europe PMC · DOI 10.64898/2026.04.20.719642