Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer’s disease
Michael A. Castello; John D. Jeppson; Salvador Soriano · 2014 · BMC Neurology
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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Abstract
BACKGROUND: High-profile Phase 3 clinical trials of bapineuzumab and solanezumab, antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. Neither drug improves clinical outcomes in patients with late onset AD, joining a long list of unsuccessful attempts to treat AD with anti-amyloid therapies. DISCUSSION: These therapies are based on the assumption that Aβ accumulation is the primary pathogenic trigger of AD. Current evidence suggests that Aβ may actually accumulate as part of an adaptive response to long-term chronic brain stress stimuli that would make
Abstract by Michael A. Castello; John D. Jeppson; Salvador Soriano, BMC Neurology (2014) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12883-014-0169-0