Negative / Null Result ReportOpen accessMedicine· cited by 48

Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort

Alexander Mihaescu; Mikaeel Valli; Carme Uribe; María Díez‐Cirarda; Mario Masellis; Ariel Graff‐Guerrero; Antonio P. Strafella · 2022 · Molecular Brain

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

The finding, in one line

“Some studies have found increased beta amyloid burden is associated with worsening cognitive impairment in Parkinson’s disease, especially in cases where dementia occurs, while other studies failed to replicate this finding.”

Abstract

Abstract The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms. Some studies have found increased beta amyloid burden is associated with worsening cognitive impairment in Parkinson’s disease, especially in cases where dementia occurs, while other studies failed to replicate this finding. To better understand this relationship, we examined a cohort of 25 idiopathic Parkinson’s disease patients and 30 healthy controls f

Abstract by Alexander Mihaescu; Mikaeel Valli; Carme Uribe; María Díez‐Cirarda; Mario Masellis; Ariel Graff‐Guerrero; Antonio P. Strafella, Molecular Brain (2022) — licensed CC BY 4.0.

Read the full paper (open access)