Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome
Wanlong Ma; Hagop M. Kantarjian; Ke Zhang; Xi Zhang; Xiuqiang Wang; Clifford Chen; Amber C. Donahue; Zhong Zhang · 2010 · BMC Medical Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Myelodysplastic syndrome (MDS) may be induced by certain mutagenic environmental or chemotherapeutic toxins; however, the role of susceptibility genes remains unclear. The G/G genotype of the single-nucleotide polymorphism (SNP) rs1617640 in the erythropoietin (EPO) promoter has been shown to be associated with decreased EPO expression. We examined the association of rs1617640 genotype with MDS. METHODS: We genotyped the EPO rS1617640 SNP in 189 patients with MDS, 257 with acute myeloid leukemia (AML), 106 with acute lymphoblastic leukemia, 97 with chronic lymphocytic leukemia, 353
Abstract by Wanlong Ma; Hagop M. Kantarjian; Ke Zhang; Xi Zhang; Xiuqiang Wang; Clifford Chen; Amber C. Donahue; Zhong Zhang, BMC Medical Genetics (2010) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1471-2350-11-163