Negative / Null Result ReportOpen accessMedicine· cited by 40

Pharmacokinetics and Pharmacodynamics of Intensive Antituberculosis Treatment of Tuberculous Meningitis

Junjie Ding; Nguyễn Thụy Thương Thương; Toi Van Pham; Dorothee Heemskerk; Thomas Pouplin; Chau Thi Hong Tran; Mai Nguyen; Phu Hoan Nguyen · 2020 · Clinical Pharmacology & Therapeutics

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

The finding, in one line

“The intensified regimen did not improve survival or any other outcome.”

Abstract

The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regimen did not improve survival or any other outcome. We therefore conducted a nested pharmacokinetic/pharmacodynamic study in 237 trial participants to define exposure-response relationships that might explain the trial results and improve future therapy. Rifampin 15 mg/kg increased plasma and cerebrospinal fluid (CSF) e

Abstract by Junjie Ding; Nguyễn Thụy Thương Thương; Toi Van Pham; Dorothee Heemskerk; Thomas Pouplin; Chau Thi Hong Tran; Mai Nguyen; Phu Hoan Nguyen, Clinical Pharmacology & Therapeutics (2020) — licensed CC BY 4.0.

Read the full paper (open access)