An open-label, single-arm, dose-escalating concentration-QT study to investigate the cardiac effects and safety of paroxetine in healthy adults.
van Dijkman SC; Félices M; Pandurangavittal B; Ghorpade S; Easterbrook C; Zabielski M; Della Pasqua O · 2026 · British journal of clinical pharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack…
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Metadata source: Europe PMC · DOI 10.1002/bcp.70398