Optimal medical care and coronary flow capacity-guided myocardial revascularization vs usual care for chronic coronary artery disease: the CENTURY trial
K. Lance Gould; Nils P. Johnson; Amanda E. Roby; Richard L. Kirkeeide; Mary Haynie; Tung Nguyen; Linh Bui; Monica Patel · 2025 · European Heart Journal
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND AND AIMS: The randomized CENTURY trial tested the hypothesis that a comprehensive strategy integrating intense lifestyle modification and aggressive medical management to goals with revascularization reserved for severely reduced coronary flow capacity (CFC) by positron emission tomography (PET) would reduce risk factors, subsequent revascularization, death and myocardial infarction (MI) compared with standard of care in chronic stable coronary artery disease (CAD). METHODS: Participants were randomly assigned to standard or comprehensive care groups. Rest-stress PET quantified CFC
Abstract by K. Lance Gould; Nils P. Johnson; Amanda E. Roby; Richard L. Kirkeeide; Mary Haynie; Tung Nguyen; Linh Bui; Monica Patel, European Heart Journal (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1093/eurheartj/ehaf356