Negative / Null Result ReportOpen accessMedicine· cited by 43

Tempol, an Intracellular Antioxidant, Inhibits Tissue Factor Expression, Attenuates Dendritic Cell Function, and Is Partially Protective in a Murine Model of Cerebral Malaria

Ivo M.B. Francischetti; Emile B. Gordon; Bruna Bizzarro; Nidhi Gera; Bruno B. Andrade; Fabiano Oliveira; Dongying Ma; Teresa C. F. Assumpção · 2014 · PLoS ONE

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. METHODS AND FINDINGS: We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant--in cells relevant to malaria pathogenesis in the context of coagulation and inflammation. Tempol was also tested in a murine model of CM induced by Plasmodium berghei Anka infection. Tempol was found to prevent transcription and functional expression of procoagulant tissue factor in endothelial cells (ECs) stimulated by lipopo

Abstract by Ivo M.B. Francischetti; Emile B. Gordon; Bruna Bizzarro; Nidhi Gera; Bruno B. Andrade; Fabiano Oliveira; Dongying Ma; Teresa C. F. Assumpção, PLoS ONE (2014) — licensed CC BY 4.0.

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