Glymphatic system impairment in cerebral small vessel disease: associations with perivascular space volume and cognition
Lulu Ai; Zhiwei Li; Huipeng Huang; Chaojuan Huang; Suhuan Chen; Xia Zhou; Xiaoqun Zhu; Zhongwu Sun · 2025 · Frontiers in Aging Neuroscience
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Objective While emerging evidence links glymphatic dysfunction to cerebral small vessel disease (CSVD), its clinical relevance remains poorly defined. This study aimed to investigate the relationships among glymphatic function, perivascular space (PVS), and cognitive performance in CSVD. Methods We enrolled 120 CSVD patients [52 with no cognitive impairment (CSVD-NCI) and 68 with mild cognitive impairment (CSVD-MCI)] and 40 healthy controls (HCs). Glymphatic function was assessed using the left ALPS index derived from diffusion tensor imaging analysis along the perivascular space (DTI-ALPS). G
Abstract by Lulu Ai; Zhiwei Li; Huipeng Huang; Chaojuan Huang; Suhuan Chen; Xia Zhou; Xiaoqun Zhu; Zhongwu Sun, Frontiers in Aging Neuroscience (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fnagi.2025.1680094