Negative / Null Result ReportOpen accessMedicine· cited by 13

The intragenic epistatic association of ADD3 with biliary atresia in Southern Han Chinese population

Zhe Wang; Xiaoli Xie; Jinglu Zhao; Ming Fu; Yonglan Li; Wei Zhong; Huimin Xia; Yan Zhang · 2018 · Bioscience Reports

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Biliary atresia (BA) is a multifactorial pathogenic disease with possible genetic components. As a member of membrane skeletal proteins in the liver and bile ducts, a haplotype composed by five single nucleotide polymorphisms (SNPs) on adducin 3 (ADD3) has been identified as associated with BA. However, limited study was designed to further elaborate the mutual relationship amongst those replicated SNPs to disease. We selected three susceptibility SNPs in ADD3 and conducted a replication study using 510 BA cases and 1473 controls to evaluate the individual function of the SNPs and further stra

Abstract by Zhe Wang; Xiaoli Xie; Jinglu Zhao; Ming Fu; Yonglan Li; Wei Zhong; Huimin Xia; Yan Zhang, Bioscience Reports (2018) — licensed CC BY 4.0.

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