Beyond Lipidation: CSF APOE4 Protein Burden, Not HDL Subclass, Drives Tau Associations in APOE4 Alzheimer’s Disease
Tsokolas ZE; Asante I; Tsiknia AA; Barbosa-Carvajal JP; Burka L; Sagare A; Cardona-Gomez GP; Mack WJ · 2026 · Preprint
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Abstract Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), yet whether its pathogenic effects are driven by HDL lipidation state or by elevated APOE4 levels in the CNS remains…
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Metadata source: Europe PMC · DOI 10.21203/rs.3.rs-9349576/v1