A current review of dose-escalated radiotherapy in locally advanced non-small cell lung cancer
Ma Li; Men Yu; Feng Lingling; Kang Jingjing; Sun Xin; Yuan Meng; Jiang Wei; Hui Zhouguang · 2019 · Radiology and Oncology
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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The finding, in one line
“However, the large randomized phase III study, RTOG 0617, failed to demonstrate the benefit of dose-escalation to 74 Gy compared with 60 Gy by simply increasing fraction numbers.”
Abstract
The mainstay therapy for locally advanced non-small cell lung cancer is concurrent chemoradiotherapy. Loco-regional recurrence constitutes the predominant failure patterns. Previous studies confirmed the relationship between increased biological equivalent doses and improved overall survival. However, the large randomized phase III study, RTOG 0617, failed to demonstrate the benefit of dose-escalation to 74 Gy compared with 60 Gy by simply increasing fraction numbers.
Abstract by Ma Li; Men Yu; Feng Lingling; Kang Jingjing; Sun Xin; Yuan Meng; Jiang Wei; Hui Zhouguang, Radiology and Oncology (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.2478/raon-2019-0006