Application and limitation of a biological clock-based method for estimating time of death in forensic practices
Akihiko Kimura; Yuko Ishida; Mizuho Nosaka; Akiko Ishigami; Hiroki Yamamoto; Yumi Kuninaka; Satoshi Hata; Mitsunori Ozaki · 2023 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Estimating time of death is one of the most important problems in forensics. Here, we evaluated the applicability, limitations and reliability of the developed biological clock-based method. We analyzed the expression of the clock genes, BMAL1 and NR1D1, in 318 dead hearts with defined time of death by real-time RT-PCR. For estimating the time of death, we chose two parameters, the NR1D1/BMAL1 ratio and BMAL1/NR1D1 ratio for morning and evening deaths, respectively. The NR1D1/BMAL1 ratio was significantly higher in morning deaths and the BMAL1/NR1D1 ratio was significantly higher in e
Abstract by Akihiko Kimura; Yuko Ishida; Mizuho Nosaka; Akiko Ishigami; Hiroki Yamamoto; Yumi Kuninaka; Satoshi Hata; Mitsunori Ozaki, Scientific Reports (2023) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1038/s41598-023-33328-3