Effects of the small molecule HERG activator NS1643 on Kv11.3 channels.
Arne Bilet; Christiane K Bauer · 2012 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents. We now investigated whether NS1643 is also able to act as an activator of Kv11.3 (erg3) channels expressed in CHO cells. Activation of rat Kv11.3 current occurred in a dose-dependent manner and maximal current increasing effects were obtained with 10 µM NS1643. At this concentration, steady-state outward current increased by about 80% and the current increase was associated with a significant shift in the voltage dependence of activation to more negative potentials b
Abstract by Arne Bilet; Christiane K Bauer, PLoS ONE (2012) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0050886