Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis
Rishi Chanderraj; Brian Bartek; Kathleen A. Stringer; Mohamad Hakam Tiba; Michael W. Sjoding; Ying He; Mark Nuppnau; Kale S. Bongers · 2026 · Journal of Clinical Investigation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUNDSepsis encompasses considerable biological and clinical heterogeneity. Previously, 2 phenotypes ("hyperinflammatory" and "hypoinflammatory") have been consistently identified within sepsis via latent class analysis. These phenotypes differ in their biological features, clinical outcomes, and therapeutic responses to interventions. Prior studies of sepsis heterogeneity have focused primarily on the host response. Here, we investigate the potential influence of the causative pathogen on sepsis heterogeneity and pathobiology.METHODSWe performed a retrospective observational analysis of
Abstract by Rishi Chanderraj; Brian Bartek; Kathleen A. Stringer; Mohamad Hakam Tiba; Michael W. Sjoding; Ying He; Mark Nuppnau; Kale S. Bongers, Journal of Clinical Investigation (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1172/jci197346