Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration
Xuanyu Qi; Guangzheng YANG; Zeqian Xu; M F Zhou; Tejing Liu; Lü B; Sihan Lin; Xinquan Jiang · 2026 · Bone Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Nociceptive pain is a cardinal feature of traumatic and inflammatory bone diseases. However, whether and how nociceptors actively regulate the immune response during bone regeneration remains unclear. Here, we found that neutrophil-triggered nociceptive ingrowth functioned as negative feedback regulation to inflammation during bone healing. A unique Il4ra + Ccl2 high neutrophil subset drove intense postinjury TRPV1 + nociceptive ingrowth, which in return dissipated inflammation by activating the production of pro-resolving mediator lipoxin A4 (LXA4) in osteoblasts. Mechanistically, os
Abstract by Xuanyu Qi; Guangzheng YANG; Zeqian Xu; M F Zhou; Tejing Liu; Lü B; Sihan Lin; Xinquan Jiang, Bone Research (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41413-025-00481-6