Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study
Junyi Xin; Xia Jiang; Shuai Ben; Qianyu Yuan; Li Su; Zhengdong Zhang; David C. Christiani; Mulong Du · 2022 · BMC Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: The association between vitamin E and cancer risk has been widely investigated by observational studies, but the findings remain inconclusive. Here, we aimed to evaluate the causal effect of circulating vitamin E on the risk of ten common cancers, including bladder, breast, colorectal, esophagus, lung, oral and pharynx, ovarian, pancreatic, prostate, and kidney cancer. METHODS: A Mendelian randomization (MR) analytic framework was applied to data from a cancer-specific genome-wide association study (GWAS) comprising a total of 297,699 cancer cases and 304,736 controls of European a
Abstract by Junyi Xin; Xia Jiang; Shuai Ben; Qianyu Yuan; Li Su; Zhengdong Zhang; David C. Christiani; Mulong Du, BMC Medicine (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12916-022-02366-5