Negative / Null Result ReportOpen accessMedicine· cited by 15

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

Elisa Alonso‐Perez; Marian Suarez-Gestal; Manuel Calaza; Francisco J. Blanco; Ana Suárez; María José Santos; Chryssa Papasteriades; Patrícia Carreira · 2014 · Arthritis Research & Therapy

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. METHODS: Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRS(s)). RESULTS: Our results did not r

Abstract by Elisa Alonso‐Perez; Marian Suarez-Gestal; Manuel Calaza; Francisco J. Blanco; Ana Suárez; María José Santos; Chryssa Papasteriades; Patrícia Carreira, Arthritis Research & Therapy (2014) — licensed CC BY 4.0.

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