Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation
Sathish Babu Vasamsetti; Samreen Sadaf; Mohammad A. Uddin; Jixing Shen; Ebin Johny; Awishi Mondal; Jonathan Florentin; Liqun Lei · 2026 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
How cellular metabolism facilitates tissue-resident macrophage maintenance remains elusive. Here we show that visceral adipose tissue (VAT)-resident macrophages, unlike monocyte-derived macrophages, are enriched with mitochondrial-specific antioxidant enzymes restraining inflammation and promoting VAT homeostasis and insulin sensitivity. Additionally, VAT resident macrophages express high levels of plasminogen activator inhibitor type 2, encoded by SerpinB2, which is involved in the blood coagulation cascade. SerpinB2 promotes adipose resident macrophage survival by regulating mitochondrial ox
Abstract by Sathish Babu Vasamsetti; Samreen Sadaf; Mohammad A. Uddin; Jixing Shen; Ebin Johny; Awishi Mondal; Jonathan Florentin; Liqun Lei, Nature Communications (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-026-69196-4