Replication FailureOpen accessMedicine· cited by 63

A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection

Ilker Uçkay; Benjamin Kressmann; Sarah Malacarne; Anna Toumanova; Jaafar Jaafar; Daniel Lew; Benjamin A. Lipsky · 2018 · BMC Infectious Diseases

WASTE classifies this as Replication Failure · AI classification, approximate

A previously reported effect did not replicate here — verify it holds before you build on it.

Abstract

BACKGROUND: An adjunctive topical therapy with gentamicin-sponges to systemic antibiotic therapy might improve the healing of infected diabetic foot ulcers (DFUI). METHODS: Single-center, investigator-blinded pilot study, randomizing (1:1) the gentamicin-sponge with systemic antibiotic versus systemic antibiotics alone for patients with DFUI. RESULTS: We included 88 DFUI episodes with 43 patients in the gentamicin-sponge arm and 45 in the control arm. Overall, 64 (64/88; 73%) witnessed total clinical cure, 13 (15%) significant improvement, and 46 (52%) showed total eradication of all pathogens

Abstract by Ilker Uçkay; Benjamin Kressmann; Sarah Malacarne; Anna Toumanova; Jaafar Jaafar; Daniel Lew; Benjamin A. Lipsky, BMC Infectious Diseases (2018) — licensed CC BY 4.0.

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