Compensator-based small animal IMRT enables conformal preclinical dose painting: application to tumor hypoxia
Jordan M. Slagowski; Erik Pearson; Rajit Tummala; Gage Redler; Daniela Olivera Velarde; Boris Epel; Howard J. Halpern; Bulent Aydogan · 2025 · arXiv
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Techniques for preclinical intensity modulated radiation therapy are being developed to improve translation by replicating the clinical paradigm. This study presents the first treatment planning comparison between small animal IMRT (SA-IMRT) and three-dimensional conformal radiotherapy (CRT) in a model application, oxygen-guided dose painting of tumor hypoxia, using actual mouse data. A novel compensator-based platform was employed to generate SA-IMRT and CRT plans with 2-15 beam angles for seventeen mice with fibrosarcoma tumors. The whole tumor received a dose of 22.5 Gy, with a simultaneous
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Metadata source: arXiv