RETRACTED ARTICLE: Pharmacokinetics, Biodistribution, and Anti-Angiogenesis Efficacy of Diamino Propane Tetraiodothyroacetic Acid-conjugated Biodegradable Polymeric Nanoparticle
Weikun Li; Murat Yalçın; Dhruba J. Bharali; Qishan Lin; Kavitha Godugu; Kazutoshi Fujioka; Kelly A. Keating; Shaker A. Mousa · 2019 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract The anti-angiogenic agent, diamino propane tetraiodothyroacetic acid (DAT), is a thyro-integrin (integrin αvβ3) antagonist anticancer agent that works via genetic and nongenetic actions. Tetraiodothyroacetic acid (tetrac) and DAT as thyroid hormone derivatives influence gene expression after they transport across cellular membranes. To restrict the action of DAT to the integrin αvβ3 receptors on the cell surface, we used DAT-conjugated PLGA nanoparticles (NDAT) in an active targeting mode to bind to these receptors. Preparation and characterization of NDAT is described, and both in vi
Abstract by Weikun Li; Murat Yalçın; Dhruba J. Bharali; Qishan Lin; Kavitha Godugu; Kazutoshi Fujioka; Kelly A. Keating; Shaker A. Mousa, Scientific Reports (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-019-44979-6