11β-Hydroxysteroid dehydrogenase type 1 deficiency causes sexual dimorphism in body composition and bone mass in response to caloric restriction.
de Araújo IM; Le PT; de Carvalho Picoli C; Hardy R; Li Z; de Paula FJA; Rosen CJ · 2026 · JBMR plus
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Caloric restriction (CR) alters energy metabolism and increases systemic glucocorticoid production, contributing to bone loss and bone marrow adipose tissue (BMAT) expansion. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)…
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Metadata source: Europe PMC · DOI 10.1093/jbmrpl/ziag075