The Limited Utility of Synovial C-Reactive Protein in the Diagnosis of Knee and Hip Periprosthetic Joint Infection: Proposed New Diagnostic Cutoffs.
McCavitt DG; Culler MW; Palmer RC; Iyer AS; Lim MA; Lieberman JR; Heckmann ND · 2026 · The Journal of arthroplasty
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
Background The utility of synovial C-reactive protein (CRP) in diagnosing periprosthetic joint infection (PJI) remains controversial. This study examined the performance of synovial CRP for PJI diagnosis following total knee arthroplasty…
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Metadata source: Europe PMC · DOI 10.1016/j.arth.2026.02.030