Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection
Chandran Ramakrishna; Mari S. Golub; Abby J. Chiang; Teresa Hong; Markus Kalkum; Edouard M. Cantin · 2017 · Behavioural Neurology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life. We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses. We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone. Anxiety level
Abstract by Chandran Ramakrishna; Mari S. Golub; Abby J. Chiang; Teresa Hong; Markus Kalkum; Edouard M. Cantin, Behavioural Neurology (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1155/2017/5238402