Inhibition of IL-33 in Diabetic Kidney Disease: A Randomized, Placebo-Controlled Phase 2b Trial.
Hofherr A; Mäki-Petäjä K; Selvarajah V; Grice D; Bartesaghi S; Jimenez E; Pecoits-Filho R; Heerspink HJL · 2026 · Journal of the American Society of Nephrology : JASN
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Key points In 558 adults with type 2 diabetes and CKD, inhibition of IL-33 by tozorakimab was well tolerated. IL-33 signaling was blocked at all doses, eosinophil counts decreased, and urinary CC-chemokine ligand 2 decreased at the high…
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Metadata source: Europe PMC · DOI 10.1681/asn.0000000966