A novel stepwise integrative analysis pipeline reveals distinct microbiota-host interactions and link to symptoms in irritable bowel syndrome
Annikka Polster; Lena Öhman; Julien Tap; Muriel Derrien; Boris Le Nevé; Johanna Sundin; Hans Törnblom; Marija Cvijovic · 2021 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Although incompletely understood, microbiota-host interactions are assumed to be altered in irritable bowel syndrome (IBS). We, therefore, aimed to develop a novel analysis pipeline tailored for the integrative analysis of microbiota-host interactions and association to symptoms and prove its utility in a pilot cohort. A multilayer stepwise integrative analysis pipeline was developed to visualize complex variable associations. Application of the pipeline was demonstrated on a dataset of IBS patients and healthy controls (HC), using the R software package to analyze colonic host mRNA a
Abstract by Annikka Polster; Lena Öhman; Julien Tap; Muriel Derrien; Boris Le Nevé; Johanna Sundin; Hans Törnblom; Marija Cvijovic, Scientific Reports (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1038/s41598-021-84686-9