The oral VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced cholangiocarcinoma
Rachna T. Shroff; Mark Yarchoan; Ashley O’Connor; Denise Gallagher; Marianna Zahurak; Gary L. Rosner; Chimela Ohaji; Susan Sartorius‐Mergenthaler · 2017 · British Journal of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: Cholangiocarcinoma is an aggressive malignancy with limited therapeutic options. MEK inhibition and antiangiogenic therapies have individually shown modest activity in advanced cholangiocarcinoma, whereas dual inhibition of…
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Metadata source: OpenAlex · DOI 10.1038/bjc.2017.119