Engineering a Fungal Non-Reducing Polyketide Synthase with an Apparently Inactive Product-Template Domain Reveals Insights into the Catalytic Reprogramming.
Yin R; Qin Y; Liang X; Zhai Z; Zhang M; Xu D; Zhou L; Lai D · 2026 · International journal of molecular sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract (excerpt)
Fungal iterative non-reducing polyketide synthases (NR-PKS) contain a unique product template (PT) domain for aromatic cyclization. Among them, some NR-PKSs, such as the sorbicillin NR-PKS (SorB), have an apparently inactive PT. It is…
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Metadata source: Europe PMC · DOI 10.3390/ijms27125534