Negative / Null Result ReportOpen accessMedicine· cited by 42

Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane

Mats Enlund; Anders Berglund; Anna Enlund; J. Lundberg; Fredrik Wärnberg; Dong‐Xin Wang; Andreas Ekman; Rebecca Ahlstrand · 2023 · EClinicalMedicine

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Background: Anaesthesia may impact long-term cancer survival. In the Cancer and Anaesthesia study, we hypothesised that the hypnotic drug propofol will have an advantage of at least five percentage points in five-year survival over the inhalational anaesthetic sevoflurane for breast cancer surgery. Methods: From 2118 eligible breast cancer patients scheduled for primary curable, invasive breast cancer surgery, 1764 were recruited after ethical approval and individual informed consent to this open label, single-blind, randomised trial at four county- and three university hospitals in Sweden and

Abstract by Mats Enlund; Anders Berglund; Anna Enlund; J. Lundberg; Fredrik Wärnberg; Dong‐Xin Wang; Andreas Ekman; Rebecca Ahlstrand, EClinicalMedicine (2023) — licensed CC BY 4.0.

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