Microglia-derived nanovesicles synchronize macroautophagy and chaperone-mediated autophagy for Alzheimer’s disease therapy
Min Li; Min Li; Shuang Chen; Rong Guo; Mingrui Yang; Mingrui Yang; Yingke Liu; Qiang Zhang · 2025 · Signal Transduction and Targeted Therapy
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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Abstract
Dysregulated autophagy is a hallmark of Alzheimer's disease (AD), yet the extent of impairment in macroautophagy and chaperone-mediated autophagy (CMA) remains unclear. Here, we show that both pathways are disrupted in AD model mice, preceding β-amyloid accumulation and driving disease progression. However, therapeutic autophagy modulation is severely restricted by the blood-brain barrier (BBB). To overcome this, we developed Microglia-Liposome Fusion Extrusion (MiLi-FE), a method to engineer microglia-derived nanovesicles (AR@ENV) for the codelivery of AR7 (a CMA inducer) and rapamycin (a mac
Abstract by Min Li; Min Li; Shuang Chen; Rong Guo; Mingrui Yang; Mingrui Yang; Yingke Liu; Qiang Zhang, Signal Transduction and Targeted Therapy (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41392-025-02453-y