Local Ancestry Adjusted Allelic Association Analysis Robustly Captures Tuberculosis Susceptibility Loci
Yolandi Swart; Caitlin Uren; Paul D. van Helden; Eileen G. Hoal; Marlo Möller · 2021 · Frontiers in Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis , is a complex disease. The risk of developing active TB is in part determined by host genetic factors. Most genetic studies investigating TB susceptibility fail to replicate association signals particularly across diverse populations. South African populations arose because of multi-wave genetic admixture from the indigenous KhoeSan, Bantu-speaking Africans, Europeans, Southeast Asian-and East Asian populations. This has led to complex genetic admixture with heterogenous patterns of linkage disequilibrium and associated traits.
Abstract by Yolandi Swart; Caitlin Uren; Paul D. van Helden; Eileen G. Hoal; Marlo Möller, Frontiers in Genetics (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fgene.2021.716558