Development and characterisation of 3D collagen-gelatin based scaffolds for breast cancer research
John Redmond; Helen O. McCarthy; Paul Buchanan; Tanya J. Levingstone; Nicholas Dunne · 2022 · Biomaterials Advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
While 2D culture presents a useful tool for cancer research, it fails to replicate the tumor microenvironment as it lacks proper three-dimensional cell-cell/cell-matrix interactions, often resulting in exaggerated responses to therapeutic agents. 3D models that aim to overcome the issues associated with 2D culture research offer a new frontier for cancer research with cell growth, morphology and genetic properties that more closely match in vivo cancers. Herein, we aim to develop a collagen-based scaffold that supports the attachment and proliferation of breast cancer (BC) cells as a 3D cultur
Abstract by John Redmond; Helen O. McCarthy; Paul Buchanan; Tanya J. Levingstone; Nicholas Dunne, Biomaterials Advances (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.bioadv.2022.213157