Breaking the PROMISE: poor association between brain volume loss and clinical disability worsening over 2 years of follow-up in primary progressive multiple sclerosis.
Koch M; Mostert J; Strijbis EM; D'Haeseleer M; Torkildsen Ø; Comtois J; Repovic P; Uitdehaag BMJ · 2026 · Journal of neurology, neurosurgery, and psychiatry
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Phase 2 clinical trials in primary progressive multiple sclerosis (PPMS) often use MRI brain volume measures as their primary endpoint. Here, we investigate the longitudinal association between change in MRI outcomes and change…
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Metadata source: Europe PMC · DOI 10.1136/jnnp-2025-337940