Recurrent Exposure to Subclinical Lipopolysaccharide Increases Mortality and Induces Cardiac Fibrosis in Mice
Wilbur Y.W. Lew; Evelyn Bayna; Erminia Dalle Molle; Nancy D. Dalton; N. Chin Lai; Valmik Bhargava; Vincent Louie Mendiola; Paul Clopton · 2013 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Circulating subclinical lipopolysaccharide (LPS) occurs in health and disease. Ingesting high fatty meals increases LPS that cause metabolic endotoxemia. Subclinical LPS in periodontal disease may impair endothelial function. The heart may be targeted as cardiac cells express TLR4, the LPS receptor. It was hypothesized that recurrent exposure to subclinical LPS increases mortality and causes cardiac fibrosis. METHODS: C57Bl/6 mice were injected with intraperitoneal saline (control), low dose LPS (0.1 or 1 mg/kg), or moderate dose LPS (10 or 20 mg/kg), once a week for 3 months. Left
Abstract by Wilbur Y.W. Lew; Evelyn Bayna; Erminia Dalle Molle; Nancy D. Dalton; N. Chin Lai; Valmik Bhargava; Vincent Louie Mendiola; Paul Clopton, PLoS ONE (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0061057