Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma
Katja Werlenius; Sara Kinhult; Tora S. Solheim; Henriette Magelssen; David Löfgren; Munila Mudaisi; Sofia Hylin; Jir̂í Bártek · 2023 · JAMA Network Open
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized phase II/III clinical trial with parallel group design. Patients were recruited at 7 study sites in Sweden and 2 sites in Norway between January 2017 and November 2020. Eligible patients were 18 years
Abstract by Katja Werlenius; Sara Kinhult; Tora S. Solheim; Henriette Magelssen; David Löfgren; Munila Mudaisi; Sofia Hylin; Jir̂í Bártek, JAMA Network Open (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1001/jamanetworkopen.2023.4149