Long-term anticonvulsant therapy leads to low bone mineral density — evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells
Joachim Feldkamp; Andréa Becker; Otto W. Witte; D. Scharff; Werner A. Scherbaum · 2012 · Experimental and Clinical Endocrinology & Diabetes
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Anticonvulsant therapy causes changes in calcium and bone metabolism and may lead to decreased bone mass with the risk of osteoporotic fractures. The two widely used antiepileptic drugs phenytoin and carbamazepine are recognized to have…
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Metadata source: OpenAlex · DOI 10.1055/s-0032-1329213