Obeticholic Acid and Other Farnesoid-X-Receptor (FXR) Agonists in the Treatment of Liver Disorders
Stefano Fiorucci; Ginevra Urbani; Eleonora Distrutti; Michele Biagioli · 2025 · Pharmaceuticals
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The Farnesoid-X-receptor (FXR) is a bile sensor involved in the regulation of bile acid homeostasis, fibrosis, inflammation, and metabolism. Obeticholic acid (OCA), a semisynthetic derivative of chenodeoxycholic acid (CDCA), initially named 6-ethyl-CDCA or INT-747, is the first in a class of FXR ligands that have been approved for clinical use for the treatment of patients with primary biliary cholangitis (PBC) who are unresponsive or intolerant to ursodeoxycholic acid. In this narrative review, we will examine the current status and future perspective of clinical use of OCA. Based on results
Abstract by Stefano Fiorucci; Ginevra Urbani; Eleonora Distrutti; Michele Biagioli, Pharmaceuticals (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ph18091424