The administration of proton pump inhibitors with the CDK4/6 inhibitor abemaciclib does not affect the clinical outcome of metastatic breast cancer patients.
Crucitta S; Cinacchi P; Bargagna I; Biondani P; Giontella E; Palleschi M; Omarini C; Belluzzi L · 2026 · Therapeutic advances in drug safety
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib have rapidly become an established oral treatment for patients with ER+, HER2- locally advanced or metastatic breast cancer. The use of the oral route offers convenience…
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Metadata source: Europe PMC · DOI 10.1177/20420986251414591