The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages
Wenyun Zeng; Danbin Wu; Yingxin Sun; Yanrong Suo; Qun Yu; Miao Zeng; Qing Gao; Bin Yu · 2021 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract NLRP3 inflammasome is a vital player in macrophages pyroptosis, which is a type of proinflammatory cell-death and takes part in the pathogenesis of atherosclerosis. In this study, we used apoE−/− mice and ox-LDL induced THP-1 derived macrophages to explore the mechanisms of MCC950, a selective NLRP3 inhibitor in treating atherosclerosis. For the in vivo study, MCC950 was intraperitoneal injected to 8-week-old apoE−/− mice fed with high-fat diet for 12 weeks. For the in vitro study, THP-1 derived macrophages were treated with ox-LDL and MCC950 for 48 h. MCC950 administration reduced pl
Abstract by Wenyun Zeng; Danbin Wu; Yingxin Sun; Yanrong Suo; Qun Yu; Miao Zeng; Qing Gao; Bin Yu, Scientific Reports (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1038/s41598-021-98437-3