Frailty and risk of systemic atherosclerosis: A bidirectional Mendelian randomization study.
Liugang Xu; Yajun Wang; Hongyun Ji; Wei Du; Chunhui You; Jin Chen; Jianyu Jiang; Yisi Shan · 2024 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background Numerous observational studies have reported an association between frailty and atherosclerosis. However, the causal relationship between frailty and the occurrence of atherosclerosis in different anatomical sites remains unclear. we conducted a bidirectional Mendelian randomization (MR) study to evaluate the causal relationship between the frailty index (FI), and both systemic atherosclerosis and lipids. Methods We obtained summary statistics from large-scale genome-wide association studies (GWAS) of various phenotypes, including frailty (n = 175,226), coronary atherosclerosis (n =
Abstract by Liugang Xu; Yajun Wang; Hongyun Ji; Wei Du; Chunhui You; Jin Chen; Jianyu Jiang; Yisi Shan, PLoS ONE (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0304300