The COMPARE head-to-head, randomized controlled trial of SEL-212 (pegadricase plus rapamycin-containing nanoparticle, ImmTOR™) versus pegloticase for refractory gout
Herbert S. B. Baraf; Puja Khanna; Alan Kivitz; Vibeke Strand; Hyon K. Choi; Robert Terkeltaub; Nicola Dalbeth; Wesley DeHaan · 2023 · Lara D. Veeken
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
OBJECTIVES: Serum urate (SU) lowering with PEGylated uricases in gout can reduce flares and tophi. However, treatment-emergent anti-drug antibodies adversely affect safety and efficacy and the currently approved PEGylated uricase…
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Metadata source: OpenAlex · DOI 10.1093/rheumatology/kead333